The main difference is architectural flexibility and control. Traditional processors give you a black box solution where you're limited to their features and update schedule. API-first gateways give you granular control over payment flows, better error handling, and the ability to customize user experiences. For global scaling, you want real-time analytics, webhook support, and easy integration with multiple payment methods. The learning curve is steeper with API-first approaches, but the long-term benefits are significant especially if you plan to expand to new markets or add innovative payment features.